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Results Bevacizumab administered monthly was equivalent to ranibizumab administered monthly, with 8.0 and 8.5 letters gained, respectively. Bevacizumab administered as needed was equivalent to ranibizumab as needed, with 5.9 and 6.8 letters gained, respectively.
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Ranibizumab as needed was equivalent to monthly ranibizumab, although the comparison between bevacizumab as needed and monthly bevacizumab was inconclusive. The mean decrease in central retinal thickness was greater in the ranibizumab-monthly group (196 μm) than in the other groups (152 to 168 μm, P=0.03 by analysis of variance). Rates of death, myocardial infarction, and stroke were similar for patients receiving either bevacizumab or ranibizumab (P>0.20). The proportion of patients with serious systemic adverse events (primarily hospitalizations) was higher with bevacizumab than with ranibizumab (24.1% vs. 19.0%; risk ratio, 1.29; 95% confidence interval, 1.01 to 1.66), with excess events broadly distributed in disease categories not identified in previous studies as areas of concern. Figure 1 Findings on Optical Coherence Tomography.
Panel A shows an optical coherence tomogram of a normal retina, with a multilayered neurosensory retina, normal central foveal depression, and retinal pigment epithelial (RPE) cell layer. The Pirate Bay Crack Fifa 13 on this page. Panel B shows the results for a typical study patient at baseline, with a marked increase in retinal thickness caused by intraretinal fluid, subretinal fluid, and sub-RPE fluid. Panel C shows a small area of intraretinal fluid, approximately equal to the median amount of fluid that was present in patients assigned to treatment as needed who did not receive treatment even though the reading-center graders identified fluid. Panel D shows the retinal thickness at 12 months in a patient treated with ranibizumab monthly.
The retinal thickness, approximately equal to the mean thickness in the ranibizumab-monthly group, and the morphologic features of the retina are similar to normal retinal anatomy. Panel E shows the 12-month results for a patient who was treated with bevacizumab monthly. The retinal thickness, approximately equal to the mean for the bevacizumab-monthly group, and the morphologic features of the retina are also similar to normal retinal anatomy.
Panel F shows the mean change in total retinal thickness at the fovea during the first year of follow-up. Figure 2 Change in Visual-Acuity Score from Baseline to 1 Year. Panel A shows the mean change in the visual-acuity score during the first year of follow-up. Panel B shows differences between pairs of study groups in the mean change from baseline to 1 year in the visual-acuity score. The red vertical lines indicate means, and the gray bars 99. Ubiquiti Dd-wrt Install. 2% confidence intervals. Negative values reflect a greater mean increase in group 2.